Smg3

+- [Smg4](/wiki/smg4)

+**SuperMemeGuardian3** (formerly known as **SuperMarioGlitchy3**) colloquially known as **Three**, is one of the three tritagonists (alongside [<u>Bob Bobowski</u>](https://supermarioglitchy4.fandom.com/wiki/Bob_Bobowski) and [<u>Fishy Boopkins</u>](https://supermarioglitchy4.fandom.com/wiki/Fishy_Boopkins)) of the [***<u>SMG4</u>***](https://supermarioglitchy4.fandom.com/wiki/SMG4_\(series\)) series. He was the main antagonist during the Classic era, and a minor antagonist for Modern Era until The YouTube Arc, where he was once again the main antagonist. This changed when he was banished soon after the War of the Fat Italians 2020.

+He is [<u>SMG4</u>](https://supermarioglitchy4.fandom.com/wiki/SMG4)'s former evil doppelganger and arch-nemesis who was originally discovered in [<u>Super Mario 64 Bloopers: SMG4 VS SMG3</u>](https://supermarioglitchy4.fandom.com/wiki/Super_Mario_64_Bloopers:_SMG4_VS_SMG3), trying to copy SMG4's videos and had attempted to kill him ever since then. He came up with and attempted to execute many plans to destroy (or sometimes just embarrass) SMG4, even doing things such as [<u>rallying up previous villains</u>](https://supermarioglitchy4.fandom.com/wiki/Super_Mario_64_Bloopers:_SMG3%27s_plan_to_destory_SMG4_cause_he_felt_like_it), using the [<u>Nightmare Stone</u>](https://supermarioglitchy4.fandom.com/wiki/The_Nightmare_Stone) against [<u>the crew</u>](https://supermarioglitchy4.fandom.com/wiki/SMG4%27s_Gang), and temporarily teaming up with [<u>Bowser</u>](https://supermarioglitchy4.fandom.com/wiki/Bowser) to do so. However, most of his plans would fail, either due to his own incompetence or bad luck. He (and [<u>Wario</u>](https://supermarioglitchy4.fandom.com/wiki/Wario)) were the people responsible for turning [<u>Waluigi</u>](https://supermarioglitchy4.fandom.com/wiki/Waluigi) back to normal at the end of [<u>WOTFI 2018</u>](https://supermarioglitchy4.fandom.com/wiki/SMG4:_War_Of_The_Fat_Italians_2018). After the T-Pose incidents, he retired from villainy to start a therapy television series called [<u>Dr. SMG3</u>](https://supermarioglitchy4.fandom.com/wiki/Dr._SMG3), which was first seen during the climax of [<u>the Waluigi Arc</u>](https://supermarioglitchy4.fandom.com/wiki/The_Waluigi_Arc). It lasted until [<u>A Day In The Life Of Everyone</u>](https://supermarioglitchy4.fandom.com/wiki/SMG4:_A_Day_In_The_Life_Of_Everyone) where his therapy show was cancelled, and later [<u>started</u>](https://supermarioglitchy4.fandom.com/wiki/SMG4:_Mario%27s_Spicy_Day_%F0%9F%94%A5) his [<u>own production company</u>](https://supermarioglitchy4.fandom.com/wiki/Snitch_Productions) which was later destroyed, forcing him to go back to his evil ways. He eventually formed a plot to seize YouTube CEO [<u>Susan Wojcicki</u>](https://supermarioglitchy4.fandom.com/wiki/Susan_Wojcicki)'s [<u>remote</u>](https://supermarioglitchy4.fandom.com/wiki/YouTube_Remote) and used its power to erase SMG4 and Susan from existence and take his place as a YouTube juggernaut.

+## See also

+- [RNA Surveillance](/wiki/RNA_Surveillance)

+- [mRNA Degradation](/wiki/mRNA_Degradation)

+Smg3 is a crucial protein involved in the cell's intricate quality control system, particularly in the [Nonsense-mediated decay](/wiki/Nonsense-mediated_decay) pathway. It plays a vital role in surveillance, ensuring the accuracy of [Gene expression](/wiki/Gene_expression) by identifying and degrading aberrant mRNA transcripts.

+## See also

+- [RNA Surveillance](/wiki/RNA_Surveillance)

+- [mRNA Degradation](/wiki/mRNA_Degradation)

+- [Protein Synthesis](/wiki/Protein_Synthesis)